Clinical Efficacy of Intravitreal Different VEGF in Patient with Neovascular Glaucoma
1. Department of Ophthalmology, The People's Hospital, Tongren 554300, China
2. Department of Ophthalmology, Central War Zone General Hospital of the Chinese People's Liberation Army, Wuhan 430070, China
| Abstract: | Objective: To investigate the clinical efficacy of intravitreal Conbercept or Lucentis combined with Ex-Press drain implantation and panretina photocoagnlation in patient with neovascular glaucoma. Methods: A total of 60 patients (60 eyes) diagnosed with NVG from Jan. 2018 to Dec. 2020 were enrolled as the study subjects, who underwent glaucoma Ex-press drainage implantation and PRP, and intravitreal Conbercept or Lucentis 3 days before surgery. According to the random number lottery method, the patients were randomized into two groups, Conbercept group and Lucentis group, with 30 cases and 30 eyes in each group. The treatment effect for best corrected visual acuity (BCVA), intraocular pressure (IOP), status of neovascularization and complications incidence were compared between the two groups. Results: the IOP levels of patients in both groups were significantly reduced compared to those before surgery (P>0.05). At 7 days, 1 month and 3 months after treatment, IOP reduction and BCVA improvement in Conbercept group were better than those in Lucentis group (P<0.05). After 12 months of treatment, the overall success rate of the Conbercept group and the Lucentis group were 56.67% and 53.33%, respectively (P>0.05), and the complication rate was 26.67% and 36.67%, respectively (P>0.05). There was no difference in IOP reduction and BCVA improvement between the two groups at 6 and 12 months of treatment (P>0.05). Conclusion: The Clinical efficacy of intravitreal Conbercept or Lucentis combined with Ex-Press drain implantation and PRP in patient with neovascular glaucoma is definite. The short-term effect of IOP reduction and visual recovery in the Conbercept group is better than that in the Lucentis group. |
| Keywords: | Neovascular Glaucoma; Conbercept; Lucentis; Intravitreal |
| DOI: | 10.57237/j.cmf.2023.03.001 |
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Received: 14 July 2023
Accepted: 7 October 2023
Published Online: 9 October 2023
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