Research Progress of NLRP3 Inflammasome in Endometriosis
nstitute of Gonadal Hormone Shanxi Datong University, Datong Key Laboratory of Sex Hormones, The First People's Hospital of Datong, Datong 037009, China
| Abstract: | Endometriosis (EMT) refers to the growth of endometrial tissue (glands and stroma) in other parts of the uterus than the body of the uterus. It is a common clinical disease of women. Patients with EMT often suffer from dysmenorrhea, chronic pelvic pain, infertility, pelvic mass and other clinical symptoms, which affect the fertility, quality of life and health status of 6%-10% of women of childbearing age, and have a negative impact on the health of female reproductive system. Inflammation is an important factor in regulating pelvic pain in patients with EMT and is a risk factor for developing chronic pain. NLRP3 is composed of amino terminal pyranoid domain (PYD), central nucleotide binding and oligomerization domain (NOD), and C-terminal leucine-rich repeat domain (LRR), which can participate in the assembly of inflammatory bodies and constitute the innate immune system. Recent studies have found that the NLRP3 inflammatome plays an important role in endometriosis by promoting the production and secretion of pro-inflammatory factors and enhancing the migration and invasion ability of ectopic endometrial stromal cells. This article reviews the research of NLRP3 inflammatome in endometriosis, in order to provide a new method for the treatment of endometriosis. |
| Keywords: | NLRP3; Inflammasome; Endometriosis |
| DOI: | 10.57237/j.cmf.2024.01.004 |
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Received: 28 December 2023
Accepted: 3 February 2024
Published Online: 4 February 2024
Funding
| 1. | 大同市应用基础研究计划项目 (基金号: 2022063) |
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