Management of Overweight and Obese People with the Dual GIP/GLP-1 Receptor Agonist Tirzepatide: A Systematic Review
1. Department of Pharmacy, The People’s Hospital of Jianyang City, Chengdu 641400, China
2. Department of Radiology, The People’s Hospital of Jianyang City, Chengdu 641400, China
| Abstract: | Purpose Aimed to comprehensively investigate the efficacy and safety of the dual GIP/GLP-1 re-ceptor agonist Tirzepatide on overweight and obesity. Methods Embase, PubMed/Medline, Web of Science, Cochrane, CNKI, Wanfang and VIP databases were searched using standard key-words to identify all controlled trials investigating the weight loss effects of Tirzepatide. RevMan 5.3 was used for analysis. Results Eleven randomized controlled trials with 11710 participants were included in this systematic review and meta-regression analysis. The pooled findings showed that Tirzepatide vs control significantly reduced body weight (mean difference (MD): -7.38, 95% confidence interval (CI): -13.66 to -1.09, P=0.02). The results of subgroup analysis showed that the trend of weight loss is dose-dependent (5mg: MD: -6.87, 95%CI: -10.29 to -3.45, P<0.0001; 10 mg: MD: -9.62, 95%CI: -13.11 to -6.13, P<0.000 01; 15mg: MD: -11.00, 95%CI: -14.29 to -7.70, P<0.000 01). HbA1c (MD: -1.38, 95% CI: -1.52 to -1.23, P<0.000 01). The total incidence of adverse reactions in Tirzepatide vs control was significantly increased (Odds Ratio (OR): 1.57, 95%CI: 1.35 to 1.81, P<0.000 01), and these adverse reactions were even greater, especially with higher doses and duration of Tirzepatide. Conclusions The administration of Tirzepatide medication has demonstrated noteworthy effects on weight management, resulting in reductions in both body weight and HbA1c levels. These effects may potentially be dependent on the dosage administered. Consequently, for individuals with diabetes who experience significant impacts on body weight, the utilization of Tirzepatide can be regarded as a viable therapeutic approach for obese individuals. |
| Keywords: | Tirzepatide; The Dual GIP/GLP-1 Receptor Agonist; Efficacy; Safety; Systematic Review |
| DOI: | 10.57237/j.cmf.2026.01.001 |
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Received: 15 June 2025
Accepted: 8 September 2025
Published Online: 14 January 2026
Funding
| 1. | This work was financially supported by grants from the Foundation of the People’s Hospital of Jianyang (JYk202406) |
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