Effect of Direct Nicotinic Salts Laryngeal Exposure on the Physiologic Status of the Larynx
1. Shanghai New Tobacco Product Research Institute Co., Ltd, Pudong New Area, Shanghai 201315, China
2. School of Life Science and Technology, Shanghai Tech University, Shanghai 200032, China
| Abstract: | Background: The physiological effects of nicotine on the larynx are crucial for understanding its sensory impact. However, the lack of scientifically validated animal models to assess these effects has been a significant limitation in tobacco research. Objective: This study aimed to establish a novel animal model using advanced techniques to evaluate the direct physiological effects of nicotine and its salts on the larynx. Main Ideas: We utilized techniques such as oral buccal tube embedding, laryngeal electrode embedding, and real-time EMG signal recording. Mice were directly exposed to nicotine smoke, and changes in laryngeal EMG signals were dynamically monitored. The observations revealed a consistent increase in the amplitude of these signals with the duration of nicotine exposure, indicating a direct physiological effect of nicotine on the larynx. Furthermore, the effects of different nicotine salts on laryngeal physiology were objectively quantified by changes in the amplitude of electromyographic signals. Conclusion: Our study successfully established an animal model for assessing the physiological effects of direct nicotine exposure on the larynx. This model provides a valuable quantitative method for evaluating throat irritation and the sensory impact of nicotine salts, aiding in the development of safer and more satisfying tobacco products. |
| Keywords: | Nicotine; Nicotinic Salts; Throat Hit Sensation; Sensory Analysis; Laryngeal Electromyographic Signals |
| DOI: | 10.57237/j.life.2024.03.003 |
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Received: 9 May 2024
Accepted: 26 July 2024
Published Online: 29 July 2024
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