Circular RNAs as Diagnostic and Prognostic Biomarkers of Hepatocellular Carcinoma: A Meta-analysis
School of Public Health, Anhui Medical University, Hefei 230032, China
| Abstract: | High morbidity, recurrence and mortality make hepatocellular carcinoma (HCC) a leading cause of cancer-related burden and deaths. However, HCC is still hard to diagnose at an early stage and lack of prognostic evaluation methods. This meta-analysis aims to assess the overall value of circRNA in HCC diagnosis and prognosis. PubMed and Web of Science were searched up to March 2023. The diagnostic and prognostic effect were evaluated by the pooled sensitivity, specificity, and overall survival (OS). In total, 31 for diagnosis and 37 for prognosis were finally included. For diagnosis, the pooled sensitivity, specificity, and the area under curve (AUC) were 0.81 (0.73-0.87), 0.84 (0.74-0.91), and 0.90 (0.87-0.92) for upregulation; and 0.79 (0.70-0.85), 0.79 (0.73-0.83) and 0.85 (0.81-0.88) for downregulation respectively, indicating moderate diagnostic accuracy. For prognosis, downregulated circRNAs were associated with better OS (HR: 0.41, 95% CI: 0.33-0.51), while upregulated circRNAs had a negative influence on OS (HR: 1.77, 1.48-2.12). The circRNA has high diagnostic accuracy and can be used as an important biomarker to prognosticate HCC. |
| Keywords: | Circular RNA; Biomarker; HCC; Diagnosis; Prognosis |
| DOI: | 10.57237/j.mrf.2023.04.003 |
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Received: 29 August 2023
Accepted: 7 October 2023
Published Online: 9 October 2023
Funding
| 1. | 安徽高校自然科学研究项目基金 (KJ2019A0229) |
| 2. | 安徽医学高等专科学校王建华科研创新团队项目基金 (WJH2022004t) |
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