Role of Ferroptosis in Peripheral Nerve Injury
Department of Otorhinolaryngology & Head and Neck Surgery, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai 200433, China
| Abstract: | Peripheral nerve injury (PNI) is a common clinical disease, which leads to long-term impairment of motor and sensory functions and even life-long disability. Ferroptosis is a novel form of cell death, which is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. These processes are regulated by multiple cellular metabolic pathways, including iron overloading, lipid peroxidation, and the glutathione/glutathione peroxidase 4 pathway. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as nervous system diseases, ischemia-reperfusion injury and Peripheral nerve injury. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. In this review, we intend to discuss the detailed mechanisms of ferroptosis in Peripheral nerve injury and to provide new insights on targeting ferroptosis for PNI treatment. |
| Keywords: | Ferroptosis; Peripheral Nerve Injury; ROS |
| DOI: | 10.57237/j.mrf.2023.04.005 |
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Received: 31 August 2023
Accepted: 24 October 2023
Published Online: 28 October 2023
Funding
| 1. | 国家自然科学基金资助项目 (Nos. 81970868, 81400474) |
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