Effects of Antipruritic Softening Cream Combined with Ultra-Pulse CO2 Fractional Laser in Treating Hypertrophic Scars
Major of Clinical Medicine, Specialization of Dermatovenereology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, Indonesia
| Abstract: | Objective: This study aimed to evaluate the impact of a treatment combining scar antipruritic softening cream with ultra-pulsed CO2 fractional laser therapy on hypertrophic scars, comparing outcomes, safety, and other relevant factors in patients. Background: Hypertrophic scars, characterized by excessive collagen deposition following skin injury, can significantly impair skin appearance and function, leading to physical discomfort and psychological distress. Existing treatments, including laser therapy, have shown variable effectiveness, necessitating the exploration of combination therapies to enhance treatment outcomes. This study investigates the efficacy of a novel combination treatment to address both the aesthetic and symptomatic challenges posed by hypertrophic scars. Methodology: A total of 186 individuals were randomly assigned to either a test group or a control group, each consisting of 93 participants. The test group received combined treatment with scar antipruritic softening cream and ultra-pulsed CO2 fractional laser, while the control group was treated solely with the laser. The study measured and compared the overall success rate, adverse reaction rates, Vancouver Scar Scale (VSS) and Visual Analog Scale (VAS) scores, and the decrease in lesion size between the two groups over a specified treatment period. Findings: The test group exhibited an overall success rate of 91.40% and an adverse reaction rate of 3.22%, compared to the control group's rates of 84.94% and 8.60%, respectively. Post-treatment, significant improvements were observed in the test group, with lower VSS and VAS scores and greater lesion size reduction compared to the control group (P < 0.05). These findings indicate that the combination treatment not only enhances scar appearance but also reduces associated symptoms such as itching and discomfort more effectively than laser therapy alone. Conclusion: The combined application of scar antipruritic softening cream with ultra-pulsed CO2 fractional laser treatment significantly improves the management of hypertrophic scars. This approach addresses both the physical and psychological impacts of hypertrophic scars, offering a more comprehensive and effective treatment option. The study's findings support the integration of combination therapies in clinical practice to optimize patient outcomes and quality of life. |
| Keywords: | Hypertrophic Scars; Scar Antipruritic Softening Cream; Ultra-pulse CO2 Fractional Laser; Efficacy; Incidence of Adverse Reactions; VSS (Vancouver Scar Scale) Score; Lesion Reduction Area; VAS (Visual Analogue Scale) Score |
| DOI: | 10.57237/j.wjcm.2024.02.001 |
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Received: 9 April 2024
Accepted: 24 May 2024
Published Online: 27 May 2024
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