中药治疗2型糖尿病的作用及其机制研究进展
1. 天津中医药大学, 研究生院, 天津 301617
2. 天津药物研究院, 天津 300462
3. 天津市中药质量标志物重点实验室, 天津 300462
| 摘 要： | 2型糖尿病（Type 2 diabetes mellitus，T2DM）是临床常见的以糖、脂代谢紊乱为主要特征的慢性代谢性疾病，常伴有多种急性或慢性并发症，严重威胁到患者健康。近年来，糖尿病发病人数快速增长，其中T2DM患者占90%以上。目前临床上药物治疗主要以西医降糖类化药居多，配合以及时血糖检测、控糖饮食、合理运动等；而中药治疗较少。由于化药长期用药存在耐药性及血糖不稳定时的剂量不可控性，与之相比，中药则更为缓和稳定，在长期控糖用药中具有独特优势。现代药理研究表明许多用于治疗T2DM的中药中均含有多种可以降低血糖的活性成分。因此，本文基于中医基础理论，综述了传统中药在治疗T2DM中的应用及作用机制，以期中药治疗为T2DM的防治提供更多参考。 |
| 关 键 词： | 2型糖尿病; 中药; 中医基础理论; 药理作用; 作用机制 |
| DOI： | 10.57237/j.cmrd.2022.01.001 |
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收稿日期: 2022-07-28
接受日期: 2022-10-05
在线出版日期: 2022-10-27
Research Progress on the Effect and Mechanism of Traditional Chinese Medicine in the Treatment of Type 2 Diabetes Mellitus
1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. Tianjin Institute of Pharmaceutical Research, Tianjin 300462, China
| Abstract: | Type 2 diabetes mellitus (T2DM) is a common clinical chronic metabolic disease characterized by glucose and lipid metabolism disorders, which is often accompanied by a variety of acute and chronic complications, posing a serious threat to the health of patients. In recent years, the incidence of diabetes has increased rapidly, and T2DM patients account for more than 90% among them. At present, the main clinical drug treatment is Chemical medicine to reduce blood suger, with timely blood glucose detection, limiting glucose intake, regular and moderate exercise, etc. In comparison, Traditional Chinese medicine treatment is less and usually used as a kind of adjuvant medicine to treat T2DM. Due to the long-term drug resistance and the uncontrollable drug dose of chemical drugs when blood sugar is unstable, Traditional Chinese medicine, by contrast, is more moderate and stable, and has unique advantages in long-term sugar control. Modern pharmacological studies have shown that many traditional Chinese medicines used to treat T2DM contain a variety of active ingredients that can reduce blood sugar. Therefore, based on the basic theory of traditional Chinese medicine, this paper reviewed the application and mechanism of traditional Chinese medicine in order to provide more reference for the prevention and treatment of T2DM. |
| Keywords: | T2DM; Traditional Chinese Medicine; Basic Theory of Traditional Chinese Medicine; Pharmacological Effects; Mechanism of Action |
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