手性MOFs在手性拆分中的研究进展
1. 佳化化学科技发展 (上海) 有限公司, 上海 200120
2. 上海工程技术大学, 化学化工学院, 上海 201620
| 摘 要： | 手性分离对于药物开发具有重要意义，手性拆分又是众多手性分离方法中使用较为普遍的一种。金属有机框架材料（MOFs）出于其规整可调节的多孔结构，通过将高度有序的手性识别位点赋予具备高比表面积和稳定性强的MOFs就可以使其成为一种效率好、选择性高的手性识别和分离平台。后修饰法（PSM）可以在保留MOFs完整晶型的情况下引入手性分子，从而得到具有手性环境的同手性MOFs。本文对近几年手性MOFs的合成及应用、MOFs复合材料的制备应用的相关文献进行了综述。首先介绍了MOFs近年来的合成方法的进展情况，随后对后功能化的手性MOFs在手性拆分中的应用进展进行了阐述，接着对MOFs复合物的制备应用进展也做了一定的介绍。本文最后对手性MOFs在手性药物拆分领域的局限和发展做了简要介绍。 |
| 关 键 词： | 金属有机框架材料; 手性拆分; 合成方法; 研究进展 |
| DOI： | 10.57237/j.cse.2023.01.001 |
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收稿日期: 2022-12-17
接受日期: 2023-03-08
在线出版日期: 2023-05-25
Research Progress of Chiral MOFs in Chiral Resolution
1. Jiahua Science & Technology Development (Shanghai) Ltd, Shanghai 200120, China
2. School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
| Abstract: | Chiral separation is important for drug development, and chiral resolution is one of the most popular methods for chiral separation. Metal organic framework materials (MOFs), with their regular and adjustable porous structures, can be an efficient and selective platform for chiral recognition and separation by assigning highly ordered chiral recognition sites to MOFs with large specific surface area and high stability. This paper reviews the recent literature on the synthesis and application of chiral MOFs and the preparation and application of MOFs composites. Firstly, the progress of MOFs synthesis methods in recent years is introduced, followed by the progress of the application of post-functionalized chiral MOFs in chiral resolution, and then the progress of the preparation and application of MOFs complexes is also introduced. Finally, the limitations and developments of chiral MOFs in chiral drug resolution are briefly described in this paper. |
| Keywords: | MOFs; Chiral Resolution; Synthesis Method; Research Progress |
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