口腔鳞状细胞癌患者HPV感染状况Meta分析
华北理工大学, 基础医学院 (河北省慢性疾病基础医学重点实验室), 河北唐山 063210
| 摘 要： | 目的：通过Meta分析综合评估口腔鳞状细胞癌（Oral Squamous Cell Carcinoma, OSCC）与人乳头瘤病毒（Human Papillomavirus, HPV）感染的相关性。方法：以口腔鳞状细胞癌和人乳头瘤状病毒为检索词，检索PubMed、Web of Science两大数据库中有全文的英文文献，应用软件Review Manager、Stata MP 17.0对所收集数据进行统计分析，探讨口腔鳞状细胞癌发生与人乳头瘤状病毒感染的病因学关联。结果：根据筛选标准共纳入13篇文献，共有口腔鳞状细胞癌患者1026例，对照组966例；根据异质性检验结果采用随机效应模型进行Meta分析，结果显示：世界范围内口腔鳞状细胞癌患者平均HPV阳性率为31.48%，OR：3.58，95%CI：1.98~6.50，Z检验结果显示z值为4.20，P<0.05，表明口腔鳞状细胞癌的发生与HPV有相关性。亚组分析结果显示，口腔鳞状细胞癌患者性别，淋巴结转移，肿瘤分化程度，肿瘤分级，肿瘤部位，个人生活习惯（吸烟、饮酒）与HPV感染没有明显关联，而患者所在的地域与HPV感染有关，发表偏倚估计和敏感性分析结果显示不存在明显发表偏倚。结论：通过对世界范围内口腔鳞状细胞癌患者HPV感染状况进行Meta分析，发现口腔鳞状细胞癌患者所在地域与HPV感染相关。 |
| 关 键 词： | 人乳头瘤病毒; 口腔鳞状细胞癌; Meta分析 |
| DOI： | 10.57237/j.life.2024.01.001 |
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收稿日期: 2023-12-07
接受日期: 2023-12-28
在线出版日期: 2024-01-20
The Meta-analysis of HPV Infection in Patients with Oral Squamous Cell Carcinoma
(Hebei Key Laboratory for Chronic Diseases), North China University of Science and Technology, Tangshan 063210, China
| Abstract: | Objective: To comprehensively evaluate the association between Oral Squamous Cell Carcinoma (OSCC) and Human Papillomavirus (HPV) infection by Meta analysis. Methods: Using oral squamous cell carcinoma and human papillomavirus as search terms, full-text English literatures in PubMed and Web of Science were searched, and the collected data were analyzed statistically by using Review Manager and Stata MP 17.0. To investigate the etiological association between oral squamous cell carcinoma and human papillomavirus infection. Results: A total of 13 literatures were included according to the screening criteria, including 1026 patients with oral squamous cell carcinoma and 966 patients in the control group. Random effects model was used for meta-analysis based on heterogeneity test results. The results showed that the average HPV positive rate of patients with oral squamous cell carcinoma worldwide was 31.48%, OR: 3.58, 95%CI: 1. 98~6.50, Z test results showed a z value of 4.20, P<0.05, which indicated that the occurrence of oral squamous cell carcinoma is correlated with HPV. Subgroup analysis showed that gender, lymph node metastasis, degree of tumor differentiation, tumor grade, tumor site, and personal lifestyle (smoking and alcohol consumption) were not significantly associated with HPV infection in patients with oral squamous cell carcinoma, while location of patients was associated with HPV Infection. Publication bias estimation and sensitivity analysis showed no significant publication bias. Conclusion: Through a Meta analysis of HPV infection in patients with oral squamous cell carcinoma worldwide, it was found that the location of patients with oral squamous cell carcinoma was associated with HPV infection. |
| Keywords: | Human Papillomavirus; Oral Squamous Cell Carcinoma; Meta-analysis |
基金
| 1. | 河北省自然基金生物医药联合基金培育项目 (No. H2022209049) |
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