基于节点探讨提高辅助生殖助孕成功率的策略
昆明医科大学第一附属医院, 生殖遗传科, 云南昆明 650032
| 摘 要： | 近年来，受环境污染加剧、工作和生活压力增加，生育年龄后延等因素的影响，不孕不育患者的数量逐年增加，辅助生殖是解决不孕不育问题的关键技术之一。然而，辅助生殖技术助孕成功率目前在50%~60%，因此，如何提高辅助生殖助孕成功率是当前辅助生殖技术的难点。辅助生殖技术涉及多种因素和多个环节，主要包括科学备孕、不孕不育病因筛查、辅助生殖促排卵治疗、胚胎培养、胚胎移植、验孕及保胎等节点，而基于辅助生殖助孕节点分析影响辅助生殖助孕成功率的因素，如是否进行科学备孕、是否进行准确的不孕不育病因筛查、是否进行合适的促排卵、是否移植后合适的用药等，并提出对应的解决方案则是提高辅助生殖助孕成功率的核心和关键。基于此，本文围绕辅助生殖助孕节点分析影响辅助生殖助孕成功率的因素，并给出科学的解决方案，以期为提高辅助生殖助孕成功率提供参考和借鉴，具有重要的理论价值和应用前景。 |
| 关 键 词： | 辅助生殖; 试管节点; 妊娠率 |
| DOI： | 10.57237/j.mrf.2022.01.002 |
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收稿日期: 2022-09-06
接受日期: 2022-10-13
在线出版日期: 2022-11-01
Exploring the Strategy to Improve the Clinical Pregnancy Rate of Assisted Reproduction Technology (ART) Basing on ART Nodes
Department of Genetics and Reproduction, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
| Abstract: | In recent years, the numbers of infertility were increasing rapidly, which was affected by the environmental pollution, the pressure from work and life, the delay of childbearing age, and so on. The assisted reproduction technology (ART) was one of the key technologies for resolving infertility. However, the pregnancy rate of the ART ranged between 50% and 60%, thus, how to improve the pregnancy rate of ART was a hotpot in the field of ART. Lots of the nodes were included in the process of ART, including scientific preparation of pregnancy for the infertility couples, the checking of the reason for infertility, the suitable controlling ovulation stimulation strategy, embryo culturing, embryo transferring, pregnancy checking and prevention of abortion. The insufficient preparation of each node could cause the failure of ART. Thus, analyzing the factors which affected the pregnancy rate of ART, such as lacking the preparation of pregnancy, errors made in the process of diagnosis for infertility, unsuitable controlling ovulation stimulation strategy, unsuitable medicine usage after embryo transferring, and finding the possibly relevant solutions strategy to improve the pregnancy rate of ART, which would provide useful reference for improving the pregnancy rate of ART and has important theoretical value and application prospect in future in the field of human reproduction. |
| Keywords: | Assisted Reproduction Technology; ART Node; Pregnancy Rate |
基金
| 1. | 上海市胚胎源性疾病重点实验室开放课题 (She2020006) |
| 2. | 云南省科技厅面上项目 (2019FB096) |
| 3. | 昆明医科大学教改项目 (2019-JY-Y-053) |
| 4. | 云南省卫生健康委员会高层次医学学科带头人 (D-2017007) |
| 5. | 云南省高层次人才培养职称计划“名医专项” (RLMY20200017) |
| 6. | 国家自然科学基金项目 (82160281) |
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