维生素D不足的患者的微量元素和血脂的水平
昆明理工大学附属医院 (云南省第一人民医院), 内分泌代谢科, 云南昆明 650000
| 摘 要： | 本文通过招募124名维生素D不足的成人，调查他们血浆中的1,25－二羟基维生素D3（1,25(OH)2D3）、25－羟维生素D3（25(OH)D3）、微量元素（Mg、Fe、Zn、Cu）和血脂（TC、TG、LDL-C、HDL-C）的水平；本文还探讨维生素D、微量元素、血脂之间的关系。结果为：1. 男性患者的25(OH)D3、BMI指数和TG的水平均较女性高，而HDL-C水平较女性低，差异均显著（P＜0.01、P=0.026、P＜0.001、P＜0.001）。男性患者的1,25(OH)2D3水平较女性高，PTH较女性低，但无统计学差异（P＞0.05）。男性患者的Mg、Zn、Fe浓度较女性高，均有统计学差异（P＜0.001、P=0.01、P=0.014），而女性的Cu较高，但无统计学差异（P＞0.05）。2. 1,25(OH)2D3与Fe呈正相关（r=0.267，P＜0.05）。Fe与Mg、Zn都呈正相关（r=0.321，P＜0.001；r=0.341，P＜0.001）。1,25(OH)2D3/25(OH)D3与TC、TG、LDL-C均呈负相关（P＜0.05），而与HDL-C无相关性（P＞0.05）。男性患者的Fe与TG负相关性（r=-0.377，P=0.033），女性患者Fe与血脂无明显相关（P＞0.05）；女性患者的Zn与TC、TG呈正相关（r=0.238，P=0.022；r=0.255，P=0.014），而男性的Zn与血脂、Mg和Cu与血脂之间都均无明显相关性（P＞0.05）。结论：1.女性患者的维生素D3和微量元素较男性患者低，女性患者更需要补充维生素D和微量元素，而男性患者更需注意管理BMI指数和血脂。2. 维生素D、微量元素、血脂之间相互影响。 |
| 关 键 词： | 1,25－二羟基维生素D3; 25－维生素D3; 微量元素; 血脂 |
| DOI： | 10.57237/j.mrf.2023.03.002 |
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收稿日期: 2023-04-25
接受日期: 2023-05-23
在线出版日期: 2023-06-15
Gender Differences in Trace Element and Lipid Levels in Patients with Vitamin D Deficiency or Insufficiency
Department of Endocrinology and Metabolism, the Affiliated Hospital of Kunming University of Science and Technology (the First People’s Hospital of Yunnan Province), Kunming 650000, China
| Abstract: | A total of 124 adults with vitamin D deficiency or deficiency were recruited to investigate the plasma levels of 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3), 25-hydroxyvitamin D3 (25(OH)D3), trace elements (Mg, Fe, Zn, Cu) and blood lipids (TC, TG, LDL-C, HDL-C). This article also explores the relationship among vitamin D, trace elements, and blood lipids. Results: 1. The 25(OH)D3, BMI and TG levels of male patients were higher than those of female patients, while the HDL-C levels were lower, with significant differences (P < 0.01, P=0.026, P < 0.001, P < 0.001). The level of 1,25(OH)2D3 in male patients was higher than that in female patients, and the PTH was lower, but there was no statistical difference (P> 0.05). The concentrations of Mg, Zn and Fe in male patients were higher than those in female patients, with statistical differences (P<0.001, P=0.01, P=0.014), while Cu in female patients was higher, but no statistical difference (P > 0.05). 2. 1,25(OH)2D3 was positively correlated with Fe (r=0.267, P < 0.05). Fe was positively correlated with Mg and Zn (r=0.321, P < 0.001; r=0.341, P<0.001). 1,25(OH)2D3/25(OH)D3 was negatively correlated with TC, TG and LDL-C (P<0.05), but had no correlation with HDL-C (P > 0.05). There was a negative correlation between Fe and TG in male patients (r= -0.377, P=0.033), but no significant correlation between Fe and blood lipid in female patients (P > 0.05). Zn was positively correlated with TC and TG in female patients (r=0.238, P=0.022; r=0.255, P=0.014), and there was no significant correlation between Zn and blood lipid, Mg and Cu (P >0.05). Conclusions: 1. The vitamin D3 and trace elements of female patients are lower than those of male patients, so they need to supplement vitamin D and trace elements more, while male patients need to pay more attention to the management of BMI and blood lipid. 2. The interaction between vitamin D, trace elements and blood lipid. |
| Keywords: | 1,25(OH)2D3; 25(OH)D3; Race Elements; Blood Lipids |
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