铁死亡在周围神经损伤中的研究进展
中国人民解放军海军军医大学第一附属医院, 耳鼻咽喉头颈外科, 上海 200433
| 摘 要： | 周围神经损伤是常见的临床疾病，可能导致不同程度的感觉和运动功能障碍。其中，外伤性PNI较为常见，其病因包括穿透伤、挤压、拉伸、缺血、热、电休克、辐射和振动等。尽管显微外科技术发展飞速，周围神经损伤后的修复再生及功能恢复仍不满意，给患者带来沉重的身心负担。铁死亡是一种铁依赖性的细胞死亡形式，以细胞内脂质过氧化物堆积为特征，在形态、生物化学和基因水平上，均不同于目前已知的细胞凋亡、自噬、坏死、焦亡和其他形式的细胞死亡。这一过程受到多种细胞代谢途径的调节，包括铁过载、脂质过氧化和谷胱甘肽/谷胱甘肽过氧化物酶4等途径。研究发现，铁死亡在神经系统疾病中参与疾病的发生发展，并起到重要作用。周围神经损伤急性损伤期，透射电镜观察到线粒体收缩、外膜破裂和嵴消失等铁死亡的形态学特征。抑制铁死亡可以抑制周围神经损伤修复，减少线粒体损伤，促进神经功能的恢复。本文阐述了铁离子及铁死亡在周围神经损伤过程中的作用及机制，为靶向铁死亡治疗周围神经损伤提供新的理论依据。 |
| 关 键 词： | 铁死亡; 周围神经损伤; 活性氧 |
| DOI： | 10.57237/j.mrf.2023.04.005 |
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收稿日期: 2023-08-31
接受日期: 2023-10-24
在线出版日期: 2023-10-28
Role of Ferroptosis in Peripheral Nerve Injury
Department of Otorhinolaryngology & Head and Neck Surgery, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai 200433, China
| Abstract: | Peripheral nerve injury (PNI) is a common clinical disease, which leads to long-term impairment of motor and sensory functions and even life-long disability. Ferroptosis is a novel form of cell death, which is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. These processes are regulated by multiple cellular metabolic pathways, including iron overloading, lipid peroxidation, and the glutathione/glutathione peroxidase 4 pathway. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as nervous system diseases, ischemia-reperfusion injury and Peripheral nerve injury. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. In this review, we intend to discuss the detailed mechanisms of ferroptosis in Peripheral nerve injury and to provide new insights on targeting ferroptosis for PNI treatment. |
| Keywords: | Ferroptosis; Peripheral Nerve Injury; ROS |
基金
| 1. | 国家自然科学基金资助项目 (Nos. 81970868, 81400474) |
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