声波激发钛表面ZnO压电性对CaP沉积的影响
南京航空航天大学, 机电学院, 江苏南京 210016
| 摘 要： | 骨矿化过程受到压电性的作用。钛及钛合金作为生物医用材料，由于其优良的机械性能及生物学性能被广泛用作植入体材料，其本身不具备压电性，在钛表面制备一层具备良好压电性的氧化锌薄膜，有利于增强骨矿化的能力。本文研究体外环境中，声波激发的钛表面氧化锌压电性对CaP沉积的影响，为改善钛合金表面生物活性提供新的思路。以氯化锌和氢氧化钠为原料采用水热合成法在TC4薄片上制备了一层致密的纳米氧化锌薄膜。并用准静态法测量了氧化锌薄膜压电常数d33的大小，通过扁平马达振动器产生声波振动，激发氧化锌薄膜压电性，进行仿生矿化实验，研究氧化锌的压电性及马达不同振动时间对CaP沉积的影响。结果显示：用此方法制备出的氧化锌薄膜结晶性良好，纯度高多为多边形片状，长度在200-300nm不等，纵向压电常数d33在2.13-3.68pC•N-1。振动样品表面比未振动表面沉积了更多的CaP，多以CaHPO4和Ca3(PO4)2为沉积产物，1h内振动30s（共12h）的浸泡样品沉积效果最佳。 |
| 关 键 词： | 氧化锌; 压电性; 钛植入体; 羟基磷灰石 |
| DOI： | 10.57237/j.se.2023.01.003 |
View:
Downloads:
收稿日期: 2022-12-12
接受日期: 2023-01-30
在线出版日期: 2023-02-03
Effect of Piezoelectricity of ZnO on CaP Deposition on Titanium Surface by Acoustic Excitation
Mechanical and Electrical College, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
| Abstract: | The process of bone mineralization is affected by piezoelectricity. As biomedical materials, titanium and titanium alloys are widely used as implant materials due to their excellent mechanical and biological properties. They do not have piezoelectric properties. The preparation of a layer of zinc oxide film with good piezoelectric properties on the surface of titanium is conducive to enhancing the ability of bone mineralization. In this paper, the effect of the piezoelectricity of zinc oxide on the deposition of CaP on the surface of titanium alloy excited by sound waves in vitro was studied, providing a new idea for improving the surface bioactivity of titanium alloy. A dense nano ZnO film was prepared on TC4 sheet by hydrothermal synthesis using zinc chloride and sodium hydroxide as raw materials. The piezoelectric constant d33 of zinc oxide thin film was measured by quasi-static method. The piezoelectric property of zinc oxide thin film was stimulated by acoustic vibration generated by a flat motor vibrator. The biomimetic mineralization experiment was carried out to study the piezoelectric property of zinc oxide and the effect of different vibration time of the motor on CaP deposition. The results show that the ZnO thin films prepared by this method have good crystallinity, high purity and are mostly hexagonal sheets, with the length ranging from 200nm to 300nm, and the longitudinal piezoelectric constant d33 is 2.13-3.68pC•N-1. More CaP was deposited on the vibrating sample surface than on the non vibrating surface, and CaHPO4 and Ca3(PO4)2 were mostly used as the deposition products. The immersion sample that vibrated for 30s within 1h (12h in total) had the best deposition effect. |
| Keywords: | Zinc Oxide; Piezoelectricity; Titanium Implants; Hydroxyapatite |
参考文献
| [1] | Tandon B, Blaker J J, Cartmell S H. Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair [J]. Acta Biomaterialia, 2018, 73: 1-20. |
| [2] | Ribeiro C, Correia D M, Rodrigues I, et al. In vivo demonstration of the suitability of piezoelectric stimuli for bone reparation [J]. Materials Letters, 2017, 209: 118-121. |
| [3] | Hotchkiss K M, Reddy G B, Hyzy SL, et al. Titanium surface characteristics, including topography and wettability, alter macrophage activation [J]. Acta Biomaterialia, 2016, 31: 425-434. |
| [4] | Ibrahim E, Omar O, Christer D, et al. Guided bone regeneration: materials and biological mechanisms revisited [J]. European Journal of Oral Sciences, 2017, 125 (5): 315-337. |
| [5] | Jing Z H, Zhang T, Xiu P, et al. Functionalization of 3D-printed titanium alloy orthopedic implants: a literature review [J]. Biomedical Materials, 2020, 15 (5): 052003-. |
| [6] | Metwally S, Stachewicz U. Surface potential and charges impact on cell responses on biomaterials interfaces for medical applications [J]. Materials Science and Engineering: C, 2019, 104: 109883-109883. |
| [7] | Fukada E, Yasuda I. On the Piezoelectric Effect of Bone [J]. Journal of the Physical Society of Japan, 1957, 12 (10): 1158-116. |
| [8] | Park J B, Recum A F, Kenner G H, et al. Piezoelectric ceramic implants: A feasibility study [J]. Journal of Biomedical Materials Research, 1980, 14 (3): 269-277. |
| [9] | Park Y J, Hwang K S, Song J E, et al. Growth of calcium phosphate on poling treated ferroelectric BaTiO3 ceramics [J]. Biomaterials, 2002, 23 (18): 3859-3864. |
| [10] | Yufei Tang et al. Fabrication and induced mineralization of bio-piezoelectric ceramic coating on titanium alloys [J]. Ceramics International, 2020, 46 (3): 4006-4014. |
| [11] | S. Hwangbo and S. D. Kim and K. S. Hwang. In-vitro calcium phosphate formation on electrostatic sprayed – perovskite BaTiO 3 layer on Ti implant after poling treatment [J]. Ceramics International, 2015, 41 (2): 2462-2466. |
| [12] | Zanfir A V, Voicu G, Busuioc C, et al. New Coll-HA/BT composite materials for hard tissue engineering [J]. Materials Science and Engineering C-Materials for Biological Applications, 2016, 62: 795-805. |
| [13] | Wu C, Tang Y F, Mao B B, et al. Improved hydrophilicity and durability of polarized PVDF coatings on anodized titanium surfaces to enhance mineralization ability [J]. Colloids and Surfaces B: Biointerfaces, 2021, 205: 111898-111898. |
| [14] | Su Y C, Cockerill I, Wang Y D, et al. Zinc-Based Biomaterials for Regeneration and Therapy [J]. Trends in Biotechnology, 2019, 37 (4): 428-441 |
| [15] | 李晶莹, 朱斌, 张玉勤, 等. 多孔氧化锌羟基磷灰石复合材料的体内生物安全性研究 [J]. 中国修复重建外科杂志, 2021, 35 (07): 847-854. |
| [16] | Tas A C. The use of physiological solutions or media in calcium phosphate synthesis and processing [J]. Acta Biomaterialia, 2014, 10 (5): 1771-1792 |
| [17] | Gandhi A A, Wojtas M, Lang S B, et al. Piezoelectricity in Poled Hydroxyapatite Ceramics [J]. Journal of the American Ceramic Society, 2014, 97 (9): 2867-2872. |
| [18] | Jiang S Q, Pan H H, Chen Y, et al. Amorphous calcium phosphate phase-mediated crystal nucleation kinetics and pathway. [J]. Faraday discussions, 2015, 179: 451-61. |
| [19] | Müller L, Müller F A. Preparation of SBF with different HCO3- content and its influence on the composition of biomimetic apatites. [J]. Acta biomaterialia, 2006, 2 (2): 181-9. |
| [20] | Zhu P X, Masuda Y, Yonezawa T, et al. Investigation of Apatite Deposition onto Charged Surfaces in Aqueous Solutions Using a Quartz-Crystal Microbalance [J]. Journal of the American Ceramic Society, 2003, 86 (5): 782-790. |
| [21] | 万梦娇, 王长秋, 孟繁露, 等. pH值对模拟体液中羟磷灰石晶体生长的调控 [J]. 岩石矿物学杂志, 2015, 34 (06): 950-956. |
| [22] | Yoreo J J, Vekilov P G. Principles of Crystal Nucleation and Growth [J]. Reviews in Mineralogy and Geochemistry, 2003, 54 (1): 57-93. |
