Chinese Medicine Research and Development is an international, peer-reviewed open access journal dedicated to advancing research the field of Chinese medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Type 2 diabetes mellitus (T2DM) is a common clinical chronic metabolic disease characterized by glucose and lipid metabolism disorders, which is often accompanied by a variety of acute and chronic complications, posing a serious threat to the health of patients. In recent years, the incidence of diabetes has increased rapidly, and T2DM patients account for more than 90% among them. At present, the main clinical drug treatment is Chemical medicine to reduce blood suger, with timely blood glucose detection, limiting glucose intake, regular and moderate exercise, etc. In comparison, Traditional Chinese medicine treatment is less and usually used as a kind of adjuvant medicine to treat T2DM. Due to the long-term drug resistance and the uncontrollable drug dose of chemical drugs when blood sugar is unstable, Traditional Chinese medicine, by contrast, is more moderate and stable, and has unique advantages in long-term sugar control. Modern pharmacological studies have shown that many traditional Chinese medicines used to treat T2DM contain a variety of active ingredients that can reduce blood sugar. Therefore, based on the basic theory of traditional Chinese medicine, this paper reviewed the application and mechanism of traditional Chinese medicine in order to provide more reference for the prevention and treatment of T2DM.Abstract: Type 2 diabetes mellitus (T2DM) is a common clinical chronic metabolic disease characterized by glucose and lipid metabolism disorders, which is often accompanied by a variety of acute and chronic complications, posing a serious threat to the health of patients. In recent years, the incidence of diabetes has increased rapidly, and T2DM patients acc...Learn More
Abstract: The prosperity and revitalization of Chinese medicine was depended on the inheritance and innovation of traditional Chinese medicine (TCM), however, inheritance in TCM was less and innovation of TCM was insufficient, and the advantages of TCM characteristics were not highlight. With the development of the economy and the improvement of people's living quality, which has put forward higher requirements for health, as a treasure of traditional Chinese culture, TCM has the outstanding function in the field of disease prevention, disease diagnosis and treatment, chronic disease management, etc. Therefore, TCM has got rapidly development and was paid more and more attentions, thus, the demand for talents in TCM was increasing. The training model of TCM talent was related to the future development of TCM, therefore, in view of the current situation of TCM was that the inheritance of TCM was less, the sense of treatment with syndrome differentiation was also weak, the succession of teachings from a master to his disciples for TCM has changed, the characteristics of TCM were not remarkable, the fundamental research of TCM was not paid enough attention, and the quality of Chinese herbal was uneven, which seriously affected the clinical diagnosis and treatment effect of TCM, thus, in this study, we analyzed the previous issues, and further explored the application of inheritance and innovation in the training mode of TCM talents by considering the aforementioned problems, which would provide beneficial reference for cultivating the high-quality talent in the field of TCM.Abstract: The prosperity and revitalization of Chinese medicine was depended on the inheritance and innovation of traditional Chinese medicine (TCM), however, inheritance in TCM was less and innovation of TCM was insufficient, and the advantages of TCM characteristics were not highlight. With the development of the economy and the improvement of people's liv...Learn More
Abstract: Type 2 diabetes mellitus (T2D) is a heterogeneous disease with insulin deficiency and insulin resistance (IR) as the main etiology, and is often accompanied by complications. Volatile oil is a volatile oil liquid extracted from natural plants, which has many pharmacological effects such as regulating qi, relieving pain, inhibiting bacteria and reducing inflammation. In recent years, there have been numerous reports on the treatment of type 2 diabetes by natural plant volatile oil and its effective components, which has become one of the new directions in the treatment of type 2 diabetes. In this paper, the essential oil and its active components of natural plants are taken as the starting point, and the material basis, mechanism and signaling pathway of the essential oil in the treatment of type 2 diabetes mellitus and its complications at home and abroad in recent years are comprehensively analyzed and summarized. The essential oil and its active components such as carvacrol, paeonol, β-caryophylene are emphatically elaborated. IR is inhibited by protecting pancreaticβ-cells, inhibiting α-glucosidase activity, regulating the abundance and diversity of intestinal microbiota, and regulating glucose transporter 4 (GLUT4), adenylate activated protein kinase (AMPK), phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) signaling pathways. Various mechanisms of action can improve type 2 diabetes mellitus, in order to provide some reference and basis for the intervention of volatile oil in type 2 diabetes mellitus and the development of new green antidiabetic drugs.Abstract: Type 2 diabetes mellitus (T2D) is a heterogeneous disease with insulin deficiency and insulin resistance (IR) as the main etiology, and is often accompanied by complications. Volatile oil is a volatile oil liquid extracted from natural plants, which has many pharmacological effects such as regulating qi, relieving pain, inhibiting bacteria and redu...Learn More
Abstract: Chronic nephritis is a glomerular immune disease with different pathological manifestations caused by a variety of reasons. Its pathogenesis is complicated. Common triggering factors include infection (such as upper respiratory tract infection, acute gastroenteritis, etc. causing inflammatory response in the body), environmental factors and Some chemotherapy drugs, etc. Traditional Chinese medicine has a profound understanding of the treatment of chronic nephritis. By summarizing Professor Lv Renhe's theory of micro-disease in the kidneys and collaterals, this paper sorts out the main line of pathogenesis of chronic nephritis "evil-sickness-disease-disease". It is believed that the nature of the disease should be regarded as both deficiency and excess, and the disease location is in the three viscera of the lungs, spleen and kidney. The dysfunction of the lung, spleen and kidney is the key to the pathogenesis of chronic nephritis, which should be mainly based on the deficiency of the root, supplemented by the actual body. Deficiency of spleen and kidney qi is the main factor, and the main pathological products such as dampness, blood stasis, phlegm, heat, and poison are accumulated in the body, resulting in the manifestations of phlegm turbidity, blood stasis, dampness toxin, chronic disease, and constipation. The purpose is to explain that the main pathogenesis of Professor Lv Renhe's "Xie Fu - chronic disease - Zheng Jia" has guiding significance for the treatment of chronic nephritis, further deepens the understanding of the pathogenesis of chronic nephritis in clinical Chinese medicine, and enriches and develops the theory of kidney and collateral micro syndrome. Open up new ideas and methods for traditional Chinese medicine treatment of kidney disease.Abstract: Chronic nephritis is a glomerular immune disease with different pathological manifestations caused by a variety of reasons. Its pathogenesis is complicated. Common triggering factors include infection (such as upper respiratory tract infection, acute gastroenteritis, etc. causing inflammatory response in the body), environmental factors and Some ch...Learn More
Abstract: Background: Postherpetic neuralgia is one of the most common neuropathic pain. Its pathogenesis is complex, and the clinical efficacy of Chinese and western medicine is not ideal at present. The purpose of this study was to investigate the efficacy and safety of Gongshi brain acupuncture in the treatment of intractable postherpetic neuralgia, and to provide evidence for the clinical treatment of intractable postherpetic neuralgia. Objective: To observe the clinical effect of Gong Shi brain acupuncture on intractable postherpetic neuralgia. Methods: 60 cases were randomly divided into treatment group (30 cases) and control group (30 cases). The treatment group was treated with Gong's brain needle, and the observation group was treated with pregabalin capsule (produced by Pfizer) orally. The observation period of both groups was 30 days, and the last score was performed by telephone follow-up one month after the treatment. Results: VAS scores of the treatment group at the 5th, 15th, 30th day and 1 month after treatment and the control group at the 15th, 30th day and 1 month after treatment were significantly lower than those before treatment (all P<0.05). VAS scores in the treatment group were significantly lower than those in the control group at the 5th, 15th, 30th and 1 month after treatment (all P<0.05). All of them had statistical significance (P<0.05). Conclusion: Gongshi brain acupuncture in the treatment of intractable postherpetic neuralgia can significantly improve the clinical efficacy of postherpetic neuralgia, shorten the time of pain relief, significantly reduce the pain symptoms of patients, and significantly improve the quality of life of patients. It is innovative, solves the dilemma of poor long-term treatment of intractable postherpetic neuralgia, and has the characteristics of "simple, fast, standard, safe and effective". It is a treatment method worth trying and worth clinical promotion and application.Abstract: Background: Postherpetic neuralgia is one of the most common neuropathic pain. Its pathogenesis is complex, and the clinical efficacy of Chinese and western medicine is not ideal at present. The purpose of this study was to investigate the efficacy and safety of Gongshi brain acupuncture in the treatment of intractable postherpetic neuralgia, and t...Learn More
Abstract: Objective: To analyze the clinical characteristics of adverse skin reactions (ADRs) caused by ginkgolide injection, and to provide reference for the post-marketing safety study of ginkgolide injection. Methods: By participating in the treatment of a patient with suspected adverse skin reactions caused by ginkgolide injection, The patient was given target ginkgolide injection 50mg intravenously once a day for two consecutive days due to cerebral infarction. Six days after drug withdrawal, the patient developed a rash on the buttocks, and then the rash quickly spread to the whole body, resulting in skin lesions with exudation tendency, itchy skin and extensive epidermal shedding. Combined with clinical medication and the clinical characteristics of this adverse reaction, the causes and mechanisms of adverse reactions caused by ginkgolide injection were analyzed from the ingredients of ginkgolide injection and the adverse reaction reports of ginkgolide extract. Consults: The adverse reaction was analyzed as severe skin allergy caused by ginkgolide injection. After oral administration of ebastine, injection of calcium gluconate and vitamin C, and topical dehumidification and itching-relieving ointment, the skin lesions basically healed after 2 weeks. Conclusions: Cases of skin allergic reactions caused by ginkgolide injection have been reported, but clinical trials on the safety of ginkgolide injection still lack the content of post-marketing safety studies. This adverse reaction is a detailed case analysis, in order to provide reference for the content of post-marketing safety of ginkgolide injection.Abstract: Objective: To analyze the clinical characteristics of adverse skin reactions (ADRs) caused by ginkgolide injection, and to provide reference for the post-marketing safety study of ginkgolide injection. Methods: By participating in the treatment of a patient with suspected adverse skin reactions caused by ginkgolide injection, The patient was given ...Learn More
