Chinese Medicine Research and Development is an international, peer-reviewed open access journal dedicated to advancing research the field of Chinese medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Neovascularization refers to the generation of new blood vessels from the existing vascular system, which occurs in the development of various tissues and organs and in the repair of injuries, and is mainly dependent on a variety of growth factors and hypoxia-induced, and plays an important role in the complex molecular mechanisms of the development of many diseases, including tumors, diabetes mellitus, inflammation, chronic liver disease, cardiac disease, and degenerative eye disease, etc., and the inhibition or promotion of neovascularization has emerged as a potential strategy for the treatment of these diseases Inhibition or promotion of neovascularization is one of the potential strategies for the treatment of these diseases. Epigenetic inheritance refers to changes in gene expression or cellular phenotypes in which genetic information occurs through certain mechanisms or pathways that can be preserved and passed on to offspring without altering the DNA sequence. In recent years, epigenetics has played an increasingly important role in the study of angiogenesis and is involved in the normal regulation of many angiogenic pathways and disease-related abnormal processes. This review explores how epigenetics affects different aspects of angiogenesis and its treatment by Chinese medicine interventions, in order to better understand the mechanisms of disease onset and progression, and to provide new ideas for disease prevention and treatment as well as drug development.Abstract: Neovascularization refers to the generation of new blood vessels from the existing vascular system, which occurs in the development of various tissues and organs and in the repair of injuries, and is mainly dependent on a variety of growth factors and hypoxia-induced, and plays an important role in the complex molecular mechanisms of the developmen...Learn More
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder, mainly manifested by cognitive and behavioral impairments, a serious threat to life, and without specific therapeutic drugs. The combination of Polygonati rhizoma and Angelicae sinensis (CPA) conforms to the principle of Chinese medicine formulation and has good effect on the prevention and treatment of AD, but there is a lack of discussion on its target effect and clinical mechanism. In this study, the core targets and key pathways between CPA and AD were analyzed by network pharmacology and molecular docking methods. The results showed that active compounds in CPA (such as baicalin, glycyrrhizin, stigmasterol, diosgenin, cis-ligustilide, etc.) played anti-inflammatory and anti-apoptotic effects by regulating key targets (such as APP, EGFR, ESR1, PTGS2, etc.) in related signaling pathways (such as Alzheimer's disease pathway, NF-kB signaling pathways, etc. ) to reduce the aggregation of β amyloid protein and inhibit Tau hyperphosphorylation, and the core components of CPA had good molecular docking activity with the core targets of the pathway. These results indicated that CPA played a role in preventing and improving Alzheimer's disease by regulating multi-target and multi-channel. These results will provide effective treatment basis for future clinical research.Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder, mainly manifested by cognitive and behavioral impairments, a serious threat to life, and without specific therapeutic drugs. The combination of Polygonati rhizoma and Angelicae sinensis (CPA) conforms to the principle of Chinese medicine formulation and has good effect on the prevention and ...Learn More
