World Journal of Clinical Medicine is an international, peer-reviewed open access journal dedicated to advancing research the field of clinical medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Objective: This study aimed to evaluate the impact of a treatment combining scar antipruritic softening cream with ultra-pulsed CO2 fractional laser therapy on hypertrophic scars, comparing outcomes, safety, and other relevant factors in patients. Background: Hypertrophic scars, characterized by excessive collagen deposition following skin injury, can significantly impair skin appearance and function, leading to physical discomfort and psychological distress. Existing treatments, including laser therapy, have shown variable effectiveness, necessitating the exploration of combination therapies to enhance treatment outcomes. This study investigates the efficacy of a novel combination treatment to address both the aesthetic and symptomatic challenges posed by hypertrophic scars. Methodology: A total of 186 individuals were randomly assigned to either a test group or a control group, each consisting of 93 participants. The test group received combined treatment with scar antipruritic softening cream and ultra-pulsed CO2 fractional laser, while the control group was treated solely with the laser. The study measured and compared the overall success rate, adverse reaction rates, Vancouver Scar Scale (VSS) and Visual Analog Scale (VAS) scores, and the decrease in lesion size between the two groups over a specified treatment period. Findings: The test group exhibited an overall success rate of 91.40% and an adverse reaction rate of 3.22%, compared to the control group's rates of 84.94% and 8.60%, respectively. Post-treatment, significant improvements were observed in the test group, with lower VSS and VAS scores and greater lesion size reduction compared to the control group (P < 0.05). These findings indicate that the combination treatment not only enhances scar appearance but also reduces associated symptoms such as itching and discomfort more effectively than laser therapy alone. Conclusion: The combined application of scar antipruritic softening cream with ultra-pulsed CO2 fractional laser treatment significantly improves the management of hypertrophic scars. This approach addresses both the physical and psychological impacts of hypertrophic scars, offering a more comprehensive and effective treatment option. The study's findings support the integration of combination therapies in clinical practice to optimize patient outcomes and quality of life.Abstract: Objective: This study aimed to evaluate the impact of a treatment combining scar antipruritic softening cream with ultra-pulsed CO2 fractional laser therapy on hypertrophic scars, comparing outcomes, safety, and other relevant factors in patients. Background: Hypertrophic scars, characterized by excessive collagen deposition following skin injury, ...Learn More
Abstract: Objective: To study and test the critical comprehensive value of intra-abdominal pressure (IAP) in monitoring and treatment of PICU patients. Methods: Via monitoring the dynamic bladder pressure of 86 cases of severe children admitted to our PICU from September 2023 to December 2023, the influences of increased IAP on the respiratory function, blood flow dynamics and condition were analyzed. Symptomatic treatments were performed for the children with intra-abdominal hypertension. Results: In the routine examination of 86 PICU patients, the changes of heart rate, blood pressure, breathing and peripheral blood oxygen saturation before and after the first IAP monitoring had no significant differences in statistics (P>0.05). The pediatric critical illness score (PCIS) and urine volume in the group with high IAP were obviously lower, while the central venous pressure (CVP) and blood lactate level were obviously higher than those of the group with normal IAP (P<0.01). The correlation coefficient between IAP and CVP, blood lactate level were 0.417, 0.300, respectively (P<0.01). The correlation coefficient between IAP and PCIS, urine volume were -0.499, -0.483, respectively (P<0.01). After treatment to reduce intra-abdominal hypertension, PCIS, urine volume of the group with high IAP increased significantly, and CVP, blood lactate level decreased gradually (P<0.05 or P<0.01). Conclusions: The trans-bladder manometry method is high safety, feasible and small traumatic for the measurement of IAP. Dynamic monitoring of IAP in severe children has certain clinical value. Taking timely and effective treatment measures to reduce IAP can help to improve the condition of the children.Abstract: Objective: To study and test the critical comprehensive value of intra-abdominal pressure (IAP) in monitoring and treatment of PICU patients. Methods: Via monitoring the dynamic bladder pressure of 86 cases of severe children admitted to our PICU from September 2023 to December 2023, the influences of increased IAP on the respiratory function, bloo...Learn More
