Clinical Medicine Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of clinical medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Currently, liver transplantation is the best way to improve the survival rate of decompensated cirrhosis, but its application is limited due to the shortage of donors and high cost. In the recent two decades, stem cell therapy is becoming a promising frontier alternative treatment. However, because various stem cell types, sources, and routes of administration can affect the therapeutic effect, we conducted this network meta-analysis to compare the efficacy of stem cells of different types, sources and delivery routes in the treatment of chronic decompensated cirrhosis. We retrieved the literature from PubMed, Embase, Cochrane Library, Web of Science from their establishment to December 2022. Additionally, clinicaltrials.gov was looked through for trials that had not yet been published or supplemental information that had been released as of December 2022. Only randomised controlled studies were included and patients must be aged at least 18 years and older with chronic decompensated liver cirrhosis but not acute-on-chronic liver failure. The included studies could be treated with stem cells of any source, type and route of administration. The primary outcome of measurement is the model of end-stage liver disease (MELD) score. This study has been registered with INPLASY (Registration number INPLASY202310050). From 2,374 articles, we included 18 studies with 936 patients. Our analysis showed no publication bias and revealed that human umbilical cord mesenchymal stem cells administered by artery and vein (hUCMSCsAV) can significantly improve MELD score of patients with chronic decompensated cirrhosis (SUCRA: 81.7%). Other effective stem cell approaches included ABMSCsA (SCURA： 65.7%), ABMSCsSH (SUCRA: 64.5%), ABMSCsGV (SUCRA: 63.5%), APBSCsGA (SUCRA: 58.7%), ABMNCsV (SUCRA: 54.9%), ABMSCsV (47.9%), and hUCMSCsV (46%). hUCMSCsAV was identified as the superior choice, followed by ABMSCsA. While these findings are promising, further high-quality research is necessary to confirm these results.Abstract: Currently, liver transplantation is the best way to improve the survival rate of decompensated cirrhosis, but its application is limited due to the shortage of donors and high cost. In the recent two decades, stem cell therapy is becoming a promising frontier alternative treatment. However, because various stem cell types, sources, and routes of ad...Learn More
Abstract: Osteoporosis is a common clinical disease, with osteoporosis in China accounting for about 7% of the total population. As a systemic bone disease, in recent years, there has been an increasing incidence among women of childbearing age, posing a serious threat to women's health. The disease mechanism of osteoporosis is complex, involving factors such as unhealthy lifestyle and hormonal imbalance, with diverse clinical manifestations including pain, spinal deformity, and fractures. This article aims to comprehensively analyze the clinical and mechanistic issues of osteoporosis in women of childbearing age, including a systematic discussion of its epidemiological characteristics, potential risk factors, pathophysiological processes, typical clinical manifestations, and current treatment strategies. Various strategies for the prevention and treatment of osteoporosis are proposed in the article, including exercise therapy, calcium and vitamin D supplementation, traditional Chinese medicine treatments (including drug and non-drug treatments such as acupuncture and massage), surgical treatment, and physical factor therapy. Emphasis is placed on the importance of health education in preventing osteoporosis, advocating for disease prevention through improving lifestyle and dietary habits. The main goal is to provide a solid theoretical basis for the development of more scientifically effective treatment strategies, improve bone mineral density levels in postmenopausal osteoporosis patients, effectively alleviate the pain caused by the disease, significantly reduce the risk of fractures, and enhance the quality of life of women of childbearing age.Abstract: Osteoporosis is a common clinical disease, with osteoporosis in China accounting for about 7% of the total population. As a systemic bone disease, in recent years, there has been an increasing incidence among women of childbearing age, posing a serious threat to women's health. The disease mechanism of osteoporosis is complex, involving factors suc...Learn More
