Medical Research Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of medical research. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Parkinson's disease (PD) is one of the most disabling diseases in the middle-aged and elderly population. The cognitive decline of the middle-aged and elderly, such as verbal disorder and nonverbal disorder, has severely impacted their life. This paper systematically expounds the specific manifestations of Parkinson's patients with nonverbal cognitive impairment, like memory impairment, executive ability impairment and attention impairment, as well as revealing the neural mechanism behind them. The result shows that the decline of working memory may be related to the damage of the lateral frontal lobe and parietal cortex. PD patients' executive ability is mainly reflected in their difficulty in keeping balance, which is related to the reduction of the volume and surface area of their cerebral cortex. The attention of PD patients is easily diverted and damaged, associating with the hyperactivity of dopamine in midbrain, the decrease of medial prefrontal cortex and lateral prefrontal cortex. Based on these nonverbal cognitive impairment of PD patients, this paper also introduces the diagnosis methods of PD through the patients' hands and voice, the treatment of motor symptoms and non-motor symptoms, and the gait intervention methods, so as to improve people's understanding of PD patients.Abstract: Parkinson's disease (PD) is one of the most disabling diseases in the middle-aged and elderly population. The cognitive decline of the middle-aged and elderly, such as verbal disorder and nonverbal disorder, has severely impacted their life. This paper systematically expounds the specific manifestations of Parkinson's patients with nonverbal cognit...Learn More
Abstract: With the development of high-throughput sequencing (Next-generation sequencing, NGS), high-resolution chromosomal structure mutation detection, long-read sequencing and other technologies, a number of pathogenic variants were detected for patients with special genetic diseases rapidly, and new variants were discovered more and more from the patients and their family individuals. However, the evaluation and genetic consulting were main challenge for clinic staff on the uncertain relationship between the new detected variations and disease. And the evaluation of the relationships between the genetic variation and disease were challenged for the clinical doctors on how to explain the genetic reports to the patients correctly. Thus, performing evaluation for the function of the rare genetic variations in disease diagnose with the guideline of the American College of Medical Genetics Genomics and the Association for Molecular Pathology (ACMG-AMP) were necessary. In this work, the principles, ideas, databases and URLs of the relevant variations were introduced according to the research experience and relevant guidelines, the experience of our team with the classification process of genetic variants basing on the guidance of ACMG rules would benefit for helping clinical staff to evaluate the genetic variants classification and genetic consulting, and finally performing the personalized patients diagnosis and treatment based on genome sequence information and special clinical phenotypes for the genetic disease.Abstract: With the development of high-throughput sequencing (Next-generation sequencing, NGS), high-resolution chromosomal structure mutation detection, long-read sequencing and other technologies, a number of pathogenic variants were detected for patients with special genetic diseases rapidly, and new variants were discovered more and more from the patient...Learn More
Abstract: End-stage liver disease (ESLD) is ultimation of all kinds of chronic liver diseases. It is highly morbidity and mortality disease and currently no effective treatment is available. Liver transplantation (LTx) is the only way for the treatment. However, the organ source limitation interferes with clinical application of LTx. For the goal of crossing liver source shortage barrier, researches attempt to explore techniques or methods like stem cells and tissue engineering, and recent years sounds developed rapidly and bright prospects, for example, artificial liver, tissue-engineered liver and xenotransplantation etc., in particular adult stem cells like bone marrow-derived mesenchymal stem cells (BMMSCs) and decellularized liver scaffold for large scale liver tissue engineer seems more eye-catching, and such decellularization / recellularization technology used has become the first strategy to build complex organs. We have previously discussed some points in the about optimizing bioscaffold materials that probably will be benificial for tissue engineer. In the present review, we would like to discuss some new developments based on research status and provide a little new thoughts, hopefully those can help people in this field in order to treat ESLD in the near future.Abstract: End-stage liver disease (ESLD) is ultimation of all kinds of chronic liver diseases. It is highly morbidity and mortality disease and currently no effective treatment is available. Liver transplantation (LTx) is the only way for the treatment. However, the organ source limitation interferes with clinical application of LTx. For the goal of crossing...Learn More
Abstract: Objective: To explore the metabolites of liver fibrosis and their interactions based on bibliometrics, and to find biomarkers and therapeutic targets for liver fibrosis. Methods: Combined Chinese and English databases were used to collect plasma metabolomics studies of liver fibrosis. Recurring metabolites from the included studies were collected as liver fibrosis metabolite profiles, and metabolites were analyzed and processed on metabolism-related databases. Results: A total of 16 articles were included, and 24 recurring metabolites were selected as the metabolite spectrum of liver fibrosis, and they appeared in 24 metabolic pathways. Topological analysis of the pathways on the MetPA database revealed that aminyl tRNA synthesis, valine, leucine and isoleucine biosynthesis, glycine, serine and threonine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, sphingolipid metabolism, phenylalanine metabolism, arginine and proline metabolism, bile acid biosynthesis, and glycolytic/glycoisogenic metabolic pathways were associated with liver fibrosis. Valine, arginine and leucine occur more than 5 times. Conclusion: The pathological mechanism of liver fibrosis involves the biological metabolism of amino acids, proteins, lipids, carbohydrates, and bile acids. Valine, arginine and leucine can be used as biomarkersof liver fibrosis.Abstract: Objective: To explore the metabolites of liver fibrosis and their interactions based on bibliometrics, and to find biomarkers and therapeutic targets for liver fibrosis. Methods: Combined Chinese and English databases were used to collect plasma metabolomics studies of liver fibrosis. Recurring metabolites from the included studies were collected a...Learn More
