Medical Research Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of medical research. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: To investigate the molecular mechanism of Ginseng and Atractylodes macrocephala in the prevention and treatment of diarrhea based on network pharmacology and molecular docking. The active ingredients and the related targets of Ginseng and Atractylodes were searched and collected through TCMSP database, PubChem database and Swiss TargetPrediction. With the help of GeneCards database, OMIM database and DisGeNET database, we searched for disease related targets with "Diarrhea" as the keyword, and the obtained targets of drug ingredients were intersected with the disease targets to obtain the results. The predicted targets of Ginseng and Atractylodes for diarrhea were obtained by intersection. Cytoscape 3.9.1 software was used to construct the "drug-active ingredient-target network" diagram. Protein interaction information was obtained by using String database, and the target network was further analyzed by CytoNCA plug-in to screen the core targets. The core targets were enriched by KEGG pathway analysis using the microbiology platform, and the results were based on the enrichment results. The KEGG enrichment analysis showed that the core targets acted on PI3K-Akt signaling pathwa, Human T-cell leukemia virus 1 ntection, Kaposi sarcoma- associated herpesvirus intection, Measles, Proteoglyeans in cancer, and 10 other pathways. Through the network pharmacology study, Ginseng and Atractylodesan regulated diarrhea involving 127 targets and 10 pathways, indicating that Ginseng and Atractylodesan can exert its effects on diarrhea prevention and treatment through multiple components, targets and pathways.Abstract: To investigate the molecular mechanism of Ginseng and Atractylodes macrocephala in the prevention and treatment of diarrhea based on network pharmacology and molecular docking. The active ingredients and the related targets of Ginseng and Atractylodes were searched and collected through TCMSP database, PubChem database and Swiss TargetPrediction. W...Learn More
Abstract: A total of 124 adults with vitamin D deficiency or deficiency were recruited to investigate the plasma levels of 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3), 25-hydroxyvitamin D3 (25(OH)D3), trace elements (Mg, Fe, Zn, Cu) and blood lipids (TC, TG, LDL-C, HDL-C). This article also explores the relationship among vitamin D, trace elements, and blood lipids. Results: 1. The 25(OH)D3, BMI and TG levels of male patients were higher than those of female patients, while the HDL-C levels were lower, with significant differences (P < 0.01, P=0.026, P < 0.001, P < 0.001). The level of 1,25(OH)2D3 in male patients was higher than that in female patients, and the PTH was lower, but there was no statistical difference (P> 0.05). The concentrations of Mg, Zn and Fe in male patients were higher than those in female patients, with statistical differences (P<0.001, P=0.01, P=0.014), while Cu in female patients was higher, but no statistical difference (P > 0.05). 2. 1,25(OH)2D3 was positively correlated with Fe (r=0.267, P < 0.05). Fe was positively correlated with Mg and Zn (r=0.321, P < 0.001; r=0.341, P<0.001). 1,25(OH)2D3/25(OH)D3 was negatively correlated with TC, TG and LDL-C (P<0.05), but had no correlation with HDL-C (P > 0.05). There was a negative correlation between Fe and TG in male patients (r= -0.377, P=0.033), but no significant correlation between Fe and blood lipid in female patients (P > 0.05). Zn was positively correlated with TC and TG in female patients (r=0.238, P=0.022; r=0.255, P=0.014), and there was no significant correlation between Zn and blood lipid, Mg and Cu (P >0.05). Conclusions: 1. The vitamin D3 and trace elements of female patients are lower than those of male patients, so they need to supplement vitamin D and trace elements more, while male patients need to pay more attention to the management of BMI and blood lipid. 2. The interaction between vitamin D, trace elements and blood lipid.Abstract: A total of 124 adults with vitamin D deficiency or deficiency were recruited to investigate the plasma levels of 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3), 25-hydroxyvitamin D3 (25(OH)D3), trace elements (Mg, Fe, Zn, Cu) and blood lipids (TC, TG, LDL-C, HDL-C). This article also explores the relationship among vitamin D, trace elements, and blood lip...Learn More
Abstract: In the 21st century, clinical medicine has entered the era of Precision medicine. Precision medicine is a new concept and medical model. With the development of modern high-tech and the Iteration and application of new ophthalmic equipment, new materials, new technologies and new methods, a precise ophthalmic diagnosis and treatment model is constructed with new concepts, It is contribute to diagnosis and treatment of common ophthalmic diseases towards development of standardized, minimally invasive, individualized and precise directions. This article introduces the precise diagnosis methods and surgical treatment status of common ophthalmic diseases in China, Prospects for the development trend of precise diagnosis and treatment in ophthalmology; among femtosecond laser assisted phacoemulsification combined with intraocular lens implantation for cataracts; corneal laser vision correction surgery (LVC, including excimer laser and femtosecond laser) for myopia and astigmatism; compound trabeculectomy and implantation of various types of drainage devices for glaucoma; photodynamic, vitrectomy and minimally invasive vitreoretinal surgery for fundus diseases; the multidisciplinary individualized treatment of orbital diseases and eye tumors is still recognized as the mainstream precision surgical treatment mode.Abstract: In the 21st century, clinical medicine has entered the era of Precision medicine. Precision medicine is a new concept and medical model. With the development of modern high-tech and the Iteration and application of new ophthalmic equipment, new materials, new technologies and new methods, a precise ophthalmic diagnosis and treatment model is constr...Learn More
Abstract: Aconitum vilmorinianum (Ranunculaceae, Aconitum) is an important traditional Chinese medicine in southwest China. It contains diterpenoid alkaloids such as yunaconitine, which have many functions, such as antirheumatic activity, improvement in human meridians, relief of swelling and pain, activation of the blood circulation, and inhibition of tumor growth. Scholars at home and abroad have carried out a lot of research work around the biology, chemical composition, pharmacological action, toxicity of Aconitine, etc. According to literature research, Yunnan is the province with the richest plant resources of the genus Aconitum. A. vilmorinianum contains 47 kinds of alkaloids, as well as flavonoids, sterols and other non alkaloid ingredients that are beneficial to human body. The research on standardized seed seedlings, planting techniques, and harvesting provides a scientific basis for the standardized production of A. vilmorinianum. The research on tissue culture, alkaloid metabolism pathways, screening of internal reference genes, and identification of blue flower genes provides reference for the application of biotechnology in A. vilmorinianum. The research on analgesic, anti-inflammatory, immune regulation, anti-tumor, and toxicity of A. vilmorinianum provides scientific reference for its clinical and development applications. Propose research directions on the pharmacological activity, resource protection, standardized production, and toxicity of A. vilmorinianum, providing reference for the comprehensive development and utilization of A. vilmorinianum.Abstract: Aconitum vilmorinianum (Ranunculaceae, Aconitum) is an important traditional Chinese medicine in southwest China. It contains diterpenoid alkaloids such as yunaconitine, which have many functions, such as antirheumatic activity, improvement in human meridians, relief of swelling and pain, activation of the blood circulation, and inhibition of tumor...Learn More
Abstract: Immunotherapy, as a revolutionary cancer treatment approach, offers an effective option for breast cancer treatment by enhancing the body's immune response, inhibiting immunosuppression, and improving anti-tumor reactions. However, the development of immunotherapy is severely limited due to the complexity of tumors and tumor immunosuppressive microenvironments. In recent years, nanotechnology has introduced new possibilities in drug research and treatment. This article mainly explores the latest advancements in breast cancer immunotherapy and its combination with nanoparticle drug targeting systems. Utilizing nanoparticles prepared through nanotechnology, precise regulation of the tumor microenvironment can be achieved, resulting in targeted local immune modulation and improved immunotherapy effects. The nanoparticle drug targeting system aims to deliver drugs directly to the tumor site, reducing damage to normal tissues and cells and decreasing drug side effects. Additionally, nanoparticle drugs can be used in conjunction with other treatments (such as chemotherapy and radiotherapy) to produce synergistic effects and further improve breast cancer treatment outcomes. This review summarizes the research progress of nanoparticle drug targeting systems in breast cancer immunotherapy, as well as their potential applications in improving the tumor microenvironment and combined therapies. It also looks forward to future opportunities and challenges.Abstract: Immunotherapy, as a revolutionary cancer treatment approach, offers an effective option for breast cancer treatment by enhancing the body's immune response, inhibiting immunosuppression, and improving anti-tumor reactions. However, the development of immunotherapy is severely limited due to the complexity of tumors and tumor immunosuppressive micro...Learn More
Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Among these patients infected with the virus, metabolic syndrome is the most common. Metabolic syndrome refers to the pathological state of various metabolic disorders in the body, which is commonly manifested as one or more symptoms such as obesity, hypertension and hyperglycemia. This article collects relevant research literature on COVID-19 patients with metabolic syndrome at home and abroad from 2020 to 2023, and reviews the epidemiological characteristics of COVID-19 patients with obesity, hypertension, hyperglycemia and other metabolic syndromes and the possible mechanism of COVID-19 susceptibility in patients with metabolic syndrome. The specific mechanism is not clear, mainly involving a series of pathways such as angiotensin-converting enzyme 2 and pro-inflammatory cytokines. It is found that patients with COVID-19 combined with metabolic syndrome have poor prognosis and increased risk of death, which has a great impact on the treatment and medication of patients. It is proposed that attention should be paid to the research on the treatment and prognosis of patients with COVID-19 complicated with metabolic syndrome, and relevant research should be carried out in depth. At the same time, it provides relevant theoretical reference for the treatment and management of patients with COVID-19 complicated with metabolic syndrome.Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Among these patients infected with the virus, metabolic syndrome is the most common. Metabolic syndrome refers to the pathological state of various metabolic disorders in the body, which is commonly manifested as one or more symptoms such as obesity, h...Learn More
Abstract: Due to the fact that both teachers and students in China are non native English speakers, using the same teaching methods as Chinese students may not necessarily be applicable to MBBS students. In order to understand the differences in the use of the most popular and mature PBL teaching method in internal medicine learning between MBBS students and Chinese students, we conducted this study. Randomly select a group of MBBS students (15 people) and a group of Chinese medical students (15 people) who will intern in Internal Medicine at the First Affiliated Hospital of Kunming Medical University in 2023 for PBL teaching with the same content. The same cases will be distributed to students in different classes in English and Chinese. At the beginning of the first class, each student will be given 10 test questions related to the case, with a total of 10 points for each question. After completing the teaching, students will be given a score, At the end of the course, 10 test questions will be given again, and students will be graded for completing the test questions in class. The difference between the two test scores will be taken for statistics. At the same time, give students a questionnaire and ask them to rate based on their learning outcomes. Based on the above scores, the following results can be obtained: both MBBS students and Chinese students feel that the arrangement of this course is basically reasonable, and they have learned new knowledge through this course. However, MBBS students believe that PBL requires too much time, which increases their learning burden, because in the second question ” Do you have enough time for such learning”, the average score given by MBBS students is 3.2667 ± 1.0328, which is significantly lower than the 4.4667 ± 0.6399 * score of Chinese students (P<0.01). Based on the research results, we explored the reasons and solutions for the above results.Abstract: Due to the fact that both teachers and students in China are non native English speakers, using the same teaching methods as Chinese students may not necessarily be applicable to MBBS students. In order to understand the differences in the use of the most popular and mature PBL teaching method in internal medicine learning between MBBS students and...Learn More
