Medical Research Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of medical research. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Since the continuous mutation of SARS-CoV-2, it became new challenges to the global COVID-19 epidemic, including vaccine prevention and treatment. Because of the global pandemic Omicron strain, which had been dominant epidemic strain, the new innovative vaccine had been improved into an important field, by global scientists. Live attenuated vaccines (LAV) had played a key role in the global action plan to eliminate polio, measles and other important infectious diseases. Additionally, LAV had advanced practical experience in the prevention and control of animal coronaviruses. So the LAV of SARS-CoV-2 should be seriously considered as a useful and important way. In this review, it analyzed its necessity from coronavirus serotype and epidemic R0 trend, and studied its feasibility from the application of animal coronavirus LAV. Herein, it focused on the four kinds of SARS-CoV-2 LAV that had completed their preclinical studies, COVI-VAC, d16, CPD and VAS5. Regarding their design principles, the growth characteristics of attenuated strains, their safety and immunogenicity in animal model and their cross-protection effects, these were all analyzed and discussed. So, the SARS-CoV-2 LAV had a solid theoretical and practical foundation, base on the modern vaccinology and genomics progress.Abstract: Since the continuous mutation of SARS-CoV-2, it became new challenges to the global COVID-19 epidemic, including vaccine prevention and treatment. Because of the global pandemic Omicron strain, which had been dominant epidemic strain, the new innovative vaccine had been improved into an important field, by global scientists. Live attenuated vaccine...Learn More
Abstract: AMPK is an important regulator of cellular glycolipid metabolism and is in-volved in inflammation and oxidative stress in various diseases. AMPK is closely related to a family of nucleotide-binding oligomeric domain-like receptors, and activation of the AMPK signaling pathway prevents the assembly and activation of NLRP3 inflammatory vesicles, inflammatory vesicles are a series of protein complexes that mediate the maturation and release of the downstream inflammatory factors interleukin-18 (IL-18) and interleukin 1β (IL-1β), leading to apoptosis and causing a series of inflammatory responses. AMPK enhances cellular utilization of energy by activating oxidation and increasing uptake of glucose and fatty acids; there-fore, disruption of AMPK activity may lead to cellular Energy destruction and metabolic disorders leading to inflammation, which is involved in metabolic syndromes (MS) through various mechanisms, and inflammatory mechanisms have become an important research direction in the pathogenesis of MS; exercise has been shown to play a key role in regulating inflammation, but the mechanisms by which exercise regulates inflammatory vesicle activation are largely un-known. Therefore, investigating whether the effects of exercise on metabolic syndrome are mediated through AMPK-NLRP3 transduction mechanisms could provide a scientific rationale and new therapeutic targets for the treatment of metabolic diseases associated with inflammatory vesicles.Abstract: AMPK is an important regulator of cellular glycolipid metabolism and is in-volved in inflammation and oxidative stress in various diseases. AMPK is closely related to a family of nucleotide-binding oligomeric domain-like receptors, and activation of the AMPK signaling pathway prevents the assembly and activation of NLRP3 inflammatory vesicles, infl...Learn More
