Medical Research Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of medical research. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Background: Ventilator-associated pneumonia (VAP) is a frequent complication for those receiving invasive mechanical ventilation in the ICU, exerts significant impacts on clinical outcomes. We aimed to explore the association between LAR and 28-day mortality in those suffering from VAP. Methods: This investigation utilized clinically granular data from MIMIC-IV database. Altogether, 591 patients with VAP were ultimately collected for analysis. Participants were categorized into three groups in accordance with tertiles of LAR. The key clinical endpoint was 28-day all-cause mortality. Univariate Cox Regression, Multivariate Cox Regression, RCS (Restricted cubic spline), Kaplan–Meier curve, and Subgroup analyses were used to examine the association between LAR and 28-day mortality among critical care patients with VAP. Results: Of the VAP patients, 22.0% succumbed within the 28-day observational window. According to the multivariable Cox regression analysis, LAR independently influenced the 28-day mortality risk in VAP patients (adjusted HR = 1.22, 95% CI: 1.06~1.39, P = 0.005). Restricted cubic spline analysis revealed a positive correlation between LAR and 28-day mortality. Subgroup analyses confirmed consistent associations across diverse patient characteristics. Kaplan-Meier curves demonstrated that patients in the high-LAR group had significantly lower survival probabilities compared to the low- and medium-LAR groups, suggesting that patients with VAP who have elevated LAR face a greater risk of mortality within 28 days. Conclusion: In summary, our study revealed a positive dose-response association between LAR and 28-day mortality in patients with VAP, suggesting that LAR is identified as an independent risk factor for unfavorable clinical outcomes in this population.Abstract: Background: Ventilator-associated pneumonia (VAP) is a frequent complication for those receiving invasive mechanical ventilation in the ICU, exerts significant impacts on clinical outcomes. We aimed to explore the association between LAR and 28-day mortality in those suffering from VAP. Methods: This investigation utilized clinically granular data ...Learn More
Abstract: With the development of skin physiology and bioengineering technology, functional skin care has transformed from single-target intervention to multi-target synergistic regulation. Skin whitening and spot lightening, anti-aging and firming, and barrier repair have become the core hotspots in contemporary skin health research. Skin aging and pigmentation are synergistically driven by multiple factors such as ultraviolet radiation, oxidative stress, protein glycosylation, and barrier damage. Intervention methods targeting a single action site are difficult to solve complex skin health problems. This paper systematically reviews the core principles of multi-target synergistic regulation technology, the mechanism of action of active ingredients, the principles of formula design, and methods of efficacy evaluation, with a focus on the innovative practice of the novel Huayi Shijia series skin anti-aging technology jointly developed by the Chinese Academy of Sciences and Zhongke Jianlan in collaboration with Shangqing Ouli. This technology achieves full-chain regulation of melanin through the compounding of niacinamide, sapphire algae extract, and tranexamic acid; constructs a triple anti-aging system of “regeneration-protection-regulation” using anti-aging factors, carnosine, and signal peptides; and synergistically strengthens barrier repair through fibronectin, aloe-cactus fermentation broth, and plant extracts. In vitro cell experiments and clinical observations demonstrate that this technology can significantly inhibit melanocyte activity, promote fibroblast proliferation and collagen synthesis, and continuous use for 28 days can significantly improve skin dullness, pigmentation, fine lines, and barrier damage. This paper also discusses the application of the multi-institution collaborative innovation model in the field of skin health intervention, providing theoretical reference and practical experience for the efficient, mild, and compliant development of skin whitening, anti-aging, and barrier repair technologies.Abstract: With the development of skin physiology and bioengineering technology, functional skin care has transformed from single-target intervention to multi-target synergistic regulation. Skin whitening and spot lightening, anti-aging and firming, and barrier repair have become the core hotspots in contemporary skin health research. Skin aging and pigmenta...Learn More
